Endocrine Abstracts

Morphologically, the follicular cells of the thyroid gland on the background of chronic lymphocytic (Hashimoto) thyroiditis may exhibit atypical changes in the nucleus, expansion of the nucleus, crowding, irregularities of nuclear membranes, intranuclear grooves and purification of chromatin. Also be observed proliferative foci of thyroid follicular cells with follicular epithelial dysplasia (FED) were as presumed premalignant conditions in chronic lymphocytic thyroiditis. The...

The relationship between subclinical hypothyroidism (SH) and Atherosclerotic (At) cardiovascular diseases (CVD) has been one of the most popular and discussing topics, because the existence of a causal relationship between Hashimoto’s thyroiditis (HT), the lipid profile, and the molecular biology of the follicular epithelium has not been conclusively established. We investigated 59 patients (female), which had undergone total thyroidectomy, lobectomy. Patients were divide...

Angiogenesis is critical for tumor growth and metastatic spread. Vascular Endothelial Growth Factor (VEGF) is the most potent inducer of neovascularization, and its increased expression is associated with worse clinical outcome in many diseases. The aim of our work was to evaluate the dynamics of VEGF and CD34 molecular morphology with Follicular Epithelial Dysplasia (FED) in Thyroid neoplasm and autoimmune pathology. These markers allow accuracy distinguishing between pseudon...

The issues of Riedel’s Thyroiditis etiology are controversial: There are two different topical pathogenic theories: Riedel’s Thyroiditis as an autoimmune disease or as independent, primary fibroplastic process. Problem is to determine the possibility of malignisation in thyroid parenchym during the autoimmune thyroiditis - Hashimoto and Riedel’s. Just due this questions, In parallel to the routine histological research, has been studied follow markers: 1. Highly...

It’s have been reported, that an evidence a mixture of immune cells frequently found inside, or surrounding primary thyroid microcarcinoma. In this point of view, we support the concept, that the immune system, such autoimmune thyroid disease, may interfere or predict in thyroid carcinoma or microcarcinoma development and progression. Arising in nonneoplastic tissues, local immune response under autoimmune chronic thyroiditis would be associated with Hashimoto parenchyme ...

Our research subject is to study the importance of some favorable molecular biological markers for prognosis of premalignant characteristics of Hashimoto’s thyroiditis (HT) parenchyma. To clarify the pathogenetic link between these two pathologies (HT, PTC), we choose markers, indicating, at the one hand, on the tumor cell cycle, such Cyclin D1, at the second hand, RET/PTC rearrangement in HT, in order to determine molecular changes, connecting Hashimoto’s thyroidi...